Mechanisms of asbestos carcinogenesis and toxicity: the amphibole hypothesis revisited.
نویسندگان
چکیده
منابع مشابه
[Mechanisms of asbestos-induced carcinogenesis].
Several types of fibrous stone called asbestos have been an unexpected cause of human cancer in the history. This form of mineral is considered precious in that they are heat-, friction-, and acid-resistant, are obtained easily from mines, and can be modified to any form with many industrial merits. However, it became evident that the inspiration of asbestos causes a rare cancer called malignan...
متن کاملBiochemical mechanisms in asbestos toxicity.
The alarming hazardous nature of asbestos makes it the foremost among toxic fugitive dusts. The biochemical mechanisms responsible for the diverse biological effects of asbestos, such as fibrosis, asbestos bodies, pleural plaques, respiratory difficulty, cancer, and cytotoxicity, are being studied in this laboratory. As asbestosis progresses in guinea pigs, along with reticulum formation, lysos...
متن کاملComparative studies on the cytotoxicity of amphibole and serpentine asbestos.
The chemical and physical properties of serpentine and amphibole asbestos are considered in the context of their interaction with tissue of the tracheobronchial tree and lungs. In vitro studies in cultures of several types are evaluated and work with the erythrocyte hemolysis system is reviewed. Although fibers of the two major mineral types differ substantially, it is likely they are modified ...
متن کاملComparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona.
This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been...
متن کاملChemical characterization and reactivity of iron chelator-treated amphibole asbestos.
Iron in amphibole asbestos is implicated in the pathogenicity of inhaled fibers. Evidence includes the observation that iron chelators can suppress fiber-induced tissue damage. This is believed to occur via the diminished production of fiber-associated reactive oxygen species. The purpose of this study was to explore possible mechanisms for the reduction of fiber toxicity by iron chelator treat...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1993
ISSN: 1351-0711
DOI: 10.1136/oem.50.8.673